Irisin Regulates Heme Oxygenase-1/Adiponectin Axis in Perivascular Adipose Tissue and Improves Endothelial Dysfunction in Diet-Induced Obese Mice

Irisin Regulates Heme Oxygenase-1/Adiponectin Axis in Perivascular Adipose Tissue and Improves Endothelial Dysfunction in Diet-Induced Obese Mice

Aims: To determine whether irisin could improve endothelial dysfunction by regulating heme oxygenase-1(HO-1)/adiponectin axis in perivascular adipose tissue (PVAT) in obesity. Methods: Male C57BL/6 mice were fed with a high-fat diet (HFD) with or without irisin treatment. Endothelium-dependent vasor...

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Bibliographic Details
Main Authors: Ningning Hou, Gang Du, Fang Han, Jin Zhang, Xiaotong Jiao, Xiaodong Sun
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Endothelial function
Irisin
Heme oxygenase-1
Adiponectin
Perivascular adipose tissue
Online Access:http://prod.karger.com/Article/FullText/477864

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http://prod.karger.com/Article/FullText/477864

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