cGMP interacts with tropomyosin and downregulates actin-tropomyosin-myosin complex interaction

cGMP interacts with tropomyosin and downregulates actin-tropomyosin-myosin complex interaction

Abstract Background The nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO-sGC-cGMP) signaling pathway, plays a critical role in the pathogenesis of pulmonary arterial hypertension (PAH); however, its exact molecular mechanism remains undefined. Methods Biotin-cGMP pull-down a...

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Bibliographic Details
Main Authors: Lihui Zou, Junhua Zhang, Jingli Han, Wenqing Li, Fei Su, Xiaomao Xu, Zhenguo Zhai, Fei Xiao
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Respiratory Research
Subjects:
Cyclic guanosine monophosphate
Tropomyosin
Actin
Myosin
Interaction
Online Access:http://link.springer.com/article/10.1186/s12931-018-0903-z

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http://link.springer.com/article/10.1186/s12931-018-0903-z

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