Blockade of Human α7 Nicotinic Acetylcholine Receptor by α-Conotoxin ImI Dendrimer: Insight from Computational Simulations

Blockade of Human α7 Nicotinic Acetylcholine Receptor by α-Conotoxin ImI Dendrimer: Insight from Computational Simulations

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that are involved in fast synaptic transmission and mediated physiological activities in the nervous system. α-Conotoxin ImI exhibits subtype-specific blockade towards homomeric α7 and α9 receptors. I...

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Bibliographic Details
Main Authors: Xiaoxiao Xu, Jiazhen Liang, Zheyu Zhang, Tao Jiang, Rilei Yu
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Marine Drugs
Subjects:
2×ImI-dendrimer
hα7 nAChR
linker
binding affinity
molecular dynamics simulation
MMGB/SA
Online Access:https://www.mdpi.com/1660-3397/17/5/303

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https://www.mdpi.com/1660-3397/17/5/303

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