PIK3CA Mutation in Colorectal Cancer: Relationship with Genetic and Epigenetic Alterations

PIK3CA Mutation in Colorectal Cancer: Relationship with Genetic and Epigenetic Alterations

Somatic PIK3CA mutations are often present in colorectal cancer. Mutant PIK3CA activates AKT signaling, which up-regulates fatty acid synthase (FASN). Microsatellite instability (MSI) and CpG island methylator phenotype (CIMP) are important molecular classifiers in colorectal cancer. However, the r...

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Bibliographic Details
Main Authors: Katsuhiko Nosho, Takako Kawasaki, Janina A. Longtine, Charles S. Fuchs, Mutsuko Ohnishi, Yuko Suemoto, Gregory J. Kirkner, Dimity Zepf, Liying Yan, Shuji Ogino
Format: Article
Language:English
Published: Elsevier 2008-06-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S147655860880142X

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http://www.sciencedirect.com/science/article/pii/S147655860880142X

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