Perturbations in small molecule synthesis uncovers an iron-responsive secondary metabolite network in Aspergillus fumigatus
Iron plays a critical role in survival and virulence of the opportunistic pathogen Aspergillus fumigatus. Two transcription factors, the GATA-factor SreA and the bZip-factor HapX oppositely monitor iron homeostasis with HapX activating iron acquisition pathways (e.g. siderophores) and shutting down...
Main Authors: | Philipp eWiemann, Beatrix E. Lechner, Joshua A. Baccile, Thomas A. Velk, Wen-Bing eYin, Jin Woo eBok, Liliana eLosada, Suman ePakala, William C. Nierman, Frank C. Schroeder, Hubertus eHaas, Nancy P. Keller |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2014-10-01
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Series: | Frontiers in Microbiology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00530/full |
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