Meglumine Antimoniate and Miltefosine Combined With Allopurinol Sustain Pro-inflammatory Immune Environments During Canine Leishmaniosis Treatment

Meglumine Antimoniate and Miltefosine Combined With Allopurinol Sustain Pro-inflammatory Immune Environments During Canine Leishmaniosis Treatment

Canine leishmaniosis (CanL) caused by Leishmania infantum is a zoonotic disease of global concern. Antileishmanial drug therapies commonly used to treat sick dogs improve their clinical condition, although when discontinued relapses can occur. Thus, the current study aims to evaluate the effect of C...

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Bibliographic Details
Main Authors: Marcos Ferreira Santos, Graça Alexandre-Pires, Maria A. Pereira, Cátia S. Marques, Joana Gomes, Jorge Correia, Ana Duarte, Lídia Gomes, Armanda V. Rodrigues, Alexandra Basso, Ana Reisinho, José Meireles, David Santos-Mateus, Maria Teresa Villa Brito, Luís Tavares, Gabriela M. Santos-Gomes, Isabel Pereira da Fonseca
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Veterinary Science
Subjects:
canine leishmaniosis
peripheral blood mononuclear cells
lymph node
bone marrow
cytokine gene expression
meglumine antimoniate
Online Access:https://www.frontiersin.org/article/10.3389/fvets.2019.00362/full

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https://www.frontiersin.org/article/10.3389/fvets.2019.00362/full

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