Low-Fat Diet With Caloric Restriction Reduces White Matter Microglia Activation During Aging

Low-Fat Diet With Caloric Restriction Reduces White Matter Microglia Activation During Aging

Rodent models of both aging and obesity are characterized by inflammation in specific brain regions, notably the corpus callosum, fornix, and hypothalamus. Microglia, the resident macrophages of the central nervous system, are important for brain development, neural support, and homeostasis. However...

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Bibliographic Details
Main Authors: Zhuoran Yin, Divya D. Raj, Wandert Schaafsma, Roel A. van der Heijden, Susanne M. Kooistra, Aaffien C. Reijne, Xiaoming Zhang, Jill Moser, Nieske Brouwer, Peter Heeringa, Chun-Xia Yi, Gertjan van Dijk, Jon D. Laman, Erik W. G. M. Boddeke, Bart J. L. Eggen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
aging
high-fat diet
low-fat diet
caloric restriction
physical exercise
microglia
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00065/full

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http://journal.frontiersin.org/article/10.3389/fnmol.2018.00065/full

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