Vienna LiverTox Workspace—A Set of Machine Learning Models for Prediction of Interactions Profiles of Small Molecules With Transporters Relevant for Regulatory Agencies

Vienna LiverTox Workspace—A Set of Machine Learning Models for Prediction of Interactions Profiles of Small Molecules With Transporters Relevant for Regulatory Agencies

Transporters expressed in the liver play a major role in drug pharmacokinetics and are a key component of the physiological bile flow. Inhibition of these transporters may lead to drug-drug interactions or even drug-induced liver injury. Therefore, predicting the interaction profile of small molecul...

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Bibliographic Details
Main Authors: Floriane Montanari, Bernhard Knasmüller, Stefan Kohlbacher, Christoph Hillisch, Christine Baierová, Melanie Grandits, Gerhard F. Ecker
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Chemistry
Subjects:
Vienna LiverTox Workspace
web service
machine learning
ABC-transporter
OATP-transporter
toxicity
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00899/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2019.00899/full

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