The non-canonical role of Aurora-A in DNA replication

The non-canonical role of Aurora-A in DNA replication

Aurora-A is a well-known mitotic kinase that regulates mitotic entry, spindle formation, and chromosome maturation as a canonical role. During mitosis, Aurora-A protein is stabilized by its phosphorylation at Ser51 via blocking anaphase promoting complex/cyclosome (APC/C)-mediated proteolysis. Impor...

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Bibliographic Details
Main Authors: Takaaki eTsunematsu, Rieko eArakaki, Akiko eYamada, Naozumi eIshimaru, Yasusei eKudo
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Oncology
Subjects:
DNA Replication
Ubiquitin
degradation
Proteasome
Aurora-A
geminin
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00187/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00187/full

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