Molecular screening of PROKR2 gene in girls with idiopathic central precocious puberty

Molecular screening of PROKR2 gene in girls with idiopathic central precocious puberty

Abstract Background Prokineticin receptor 2 (PROKR2) loss of function mutations have been described as cause of hypogonadotropic hypogonadism. In 2017, a first case of central precocious puberty (CPP) caused by PROKR2 heterozygous gain of function mutation was described in a 3.5 years-old girl. No o...

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Bibliographic Details
Main Authors: Francesca Aiello, Grazia Cirillo, Alessandra Cassio, Raffaella Di Mase, Gianluca Tornese, Giuseppina R. Umano, Emanuele Miraglia del Giudice, Anna Grandone
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Italian Journal of Pediatrics
Subjects:
PROKR2
Early central precocious puberty
Genetic screening
Online Access:https://doi.org/10.1186/s13052-020-00951-z

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https://doi.org/10.1186/s13052-020-00951-z

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