Diallyl Disulfide Induces Apoptosis and Autophagy in Human Osteosarcoma MG-63 Cells through the PI3K/Akt/mTOR Pathway

Diallyl Disulfide Induces Apoptosis and Autophagy in Human Osteosarcoma MG-63 Cells through the PI3K/Akt/mTOR Pathway

Diallyl disulfide (DADs), a natural organic compound, is extracted from garlic and scallion and has anti-tumor effects against various tumors. This study investigated the anti-tumor activity of DADs in human osteosarcoma cells and the mechanisms. MG-63 cells were exposed to DADs (0, 20, 40, 60, 80,...

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Bibliographic Details
Main Authors: Ziqi Yue, Xin Guan, Rui Chao, Cancan Huang, Dongfang Li, Panpan Yang, Shanshan Liu, Tomoka Hasegawa, Jie Guo, Minqi Li
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Molecules
Subjects:
diallyl disulfide
apoptosis
autophagy
osteosarcoma
PI3K/Akt/mTOR pathway
Online Access:https://www.mdpi.com/1420-3049/24/14/2665

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https://www.mdpi.com/1420-3049/24/14/2665

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