Comparison study of MS-HRM and pyrosequencing techniques for quantification of APC and CDKN2A gene methylation.

Comparison study of MS-HRM and pyrosequencing techniques for quantification of APC and CDKN2A gene methylation.

There is increasing interest in the development of cost-effective techniques for the quantification of DNA methylation biomarkers. We analyzed 90 samples of surgically resected colorectal cancer tissues for APC and CDKN2A promoter methylation using methylation sensitive-high resolution melting (MS-H...

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Bibliographic Details
Main Authors: Francesca Migheli, Andrea Stoccoro, Fabio Coppedè, Wan Adnan Wan Omar, Alessandra Failli, Rita Consolini, Massimo Seccia, Roberto Spisni, Paolo Miccoli, John C Mathers, Lucia Migliore
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3543439?pdf=render

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http://europepmc.org/articles/PMC3543439?pdf=render

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