Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo.

Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo.

Several people with Parkinson's disease have been treated with intrastriatal grafts of fetal dopaminergic neurons. Following autopsy, 10-22 years after surgery, some of the grafted neurons contained Lewy bodies similar to those observed in the host brain. Numerous studies have attempted to expl...

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Bibliographic Details
Main Authors: Elodie Angot, Jennifer A Steiner, Carla M Lema Tomé, Peter Ekström, Bengt Mattsson, Anders Björklund, Patrik Brundin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3380846?pdf=render

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http://europepmc.org/articles/PMC3380846?pdf=render

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