Modelling the MYC-driven normal-to-tumour switch in breast cancer

Modelling the MYC-driven normal-to-tumour switch in breast cancer

The potent MYC oncoprotein is deregulated in many human cancers, including breast carcinoma, and is associated with aggressive disease. To understand the mechanisms and vulnerabilities of MYC-driven breast cancer, we have generated an in vivo model that mimics human disease in response to MYC deregu...

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Bibliographic Details
Main Authors: Corey Lourenco, Manpreet Kalkat, Kathleen E. Houlahan, Jason De Melo, Joseph Longo, Susan J. Done, Paul C. Boutros, Linda Z. Penn
Format: Article
Language:English
Published: The Company of Biologists 2019-07-01
Series:Disease Models & Mechanisms
Subjects:
MYC
Driver oncogene
PI3K
Breast cancer
Cancer model
Microenvironment
Online Access:http://dmm.biologists.org/content/12/7/dmm038083

Internet

http://dmm.biologists.org/content/12/7/dmm038083

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