Triazoloquinazolines as a new class of potent α-glucosidase inhibitors: in vitro evaluation and docking study.
Previously, we synthesized triazoloquinazolines 1-14 and characterized their structure. In this study, we aimed to evaluate the in vitro activity of the targets 1-14 as α-glucosidase inhibitors using α-glucosidase enzyme from Saccharomyces cerevisiae type 1. Among the tested compounds, triazoloquina...
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doaj-5c5684e804314818b1c261ba55cf08592021-03-03T21:08:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01148e022037910.1371/journal.pone.0220379Triazoloquinazolines as a new class of potent α-glucosidase inhibitors: in vitro evaluation and docking study.Hatem A AbuelizzEl Hassane AnouarRohaya AhmadNor Izzati Iwana Nor AzmanMohamed MarzoukRashad Al-SalahiPreviously, we synthesized triazoloquinazolines 1-14 and characterized their structure. In this study, we aimed to evaluate the in vitro activity of the targets 1-14 as α-glucosidase inhibitors using α-glucosidase enzyme from Saccharomyces cerevisiae type 1. Among the tested compounds, triazoloquinazolines 14, 8, 4, 5, and 3 showed the highest inhibitory activity (IC50 = 12.70 ± 1.87, 28.54 ± 1.22, 45.65 ± 4.28, 72.28 ± 4.67, and 83.87 ± 5.12 μM, respectively) in relation to that of acarbose (IC50 = 143.54 ± 2.08 μM) as a reference drug. Triazoloquinazolines were identified herein as a new class of potent α-glucosidase inhibitors. Molecular docking results envisaged the plausible binding interaction between the target triazoloquinazolines and α-glucosidase enzyme and indicated considerable interaction with the active site residues.https://doi.org/10.1371/journal.pone.0220379 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hatem A Abuelizz El Hassane Anouar Rohaya Ahmad Nor Izzati Iwana Nor Azman Mohamed Marzouk Rashad Al-Salahi |
spellingShingle |
Hatem A Abuelizz El Hassane Anouar Rohaya Ahmad Nor Izzati Iwana Nor Azman Mohamed Marzouk Rashad Al-Salahi Triazoloquinazolines as a new class of potent α-glucosidase inhibitors: in vitro evaluation and docking study. PLoS ONE |
author_facet |
Hatem A Abuelizz El Hassane Anouar Rohaya Ahmad Nor Izzati Iwana Nor Azman Mohamed Marzouk Rashad Al-Salahi |
author_sort |
Hatem A Abuelizz |
title |
Triazoloquinazolines as a new class of potent α-glucosidase inhibitors: in vitro evaluation and docking study. |
title_short |
Triazoloquinazolines as a new class of potent α-glucosidase inhibitors: in vitro evaluation and docking study. |
title_full |
Triazoloquinazolines as a new class of potent α-glucosidase inhibitors: in vitro evaluation and docking study. |
title_fullStr |
Triazoloquinazolines as a new class of potent α-glucosidase inhibitors: in vitro evaluation and docking study. |
title_full_unstemmed |
Triazoloquinazolines as a new class of potent α-glucosidase inhibitors: in vitro evaluation and docking study. |
title_sort |
triazoloquinazolines as a new class of potent α-glucosidase inhibitors: in vitro evaluation and docking study. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2019-01-01 |
description |
Previously, we synthesized triazoloquinazolines 1-14 and characterized their structure. In this study, we aimed to evaluate the in vitro activity of the targets 1-14 as α-glucosidase inhibitors using α-glucosidase enzyme from Saccharomyces cerevisiae type 1. Among the tested compounds, triazoloquinazolines 14, 8, 4, 5, and 3 showed the highest inhibitory activity (IC50 = 12.70 ± 1.87, 28.54 ± 1.22, 45.65 ± 4.28, 72.28 ± 4.67, and 83.87 ± 5.12 μM, respectively) in relation to that of acarbose (IC50 = 143.54 ± 2.08 μM) as a reference drug. Triazoloquinazolines were identified herein as a new class of potent α-glucosidase inhibitors. Molecular docking results envisaged the plausible binding interaction between the target triazoloquinazolines and α-glucosidase enzyme and indicated considerable interaction with the active site residues. |
url |
https://doi.org/10.1371/journal.pone.0220379 |
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