Creation of Cybrid Cultures Containing mtDNA Mutations m.12315G>A and m.1555G>A, Associated with Atherosclerosis

Creation of Cybrid Cultures Containing mtDNA Mutations m.12315G>A and m.1555G>A, Associated with Atherosclerosis

In the present work, a pilot creation of four cybrid cultures with high heteroplasmy level was performed using mitochondrial genome mutations m.12315G>A and m.1555G>A. According to data of our preliminary studies, the threshold heteroplasmy level of mutation m.12315G>A is associ...

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Bibliographic Details
Main Authors: Margarita A. Sazonova, Vasily V. Sinyov, Anastasia I. Ryzhkova, Marina D. Sazonova, Zukhra B. Khasanova, Tatiana P. Shkurat, Vasily P. Karagodin, Alexander N. Orekhov, Igor A. Sobenin
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Biomolecules
Subjects:
cytoplasmatic hybrids
mitochondrial genome
mutation
gene
cybrids
mtDNA
therapy
cybrid model
Online Access:https://www.mdpi.com/2218-273X/9/9/499

Internet

https://www.mdpi.com/2218-273X/9/9/499

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