Estimation of immune cell content in tumour tissue using single-cell RNA-seq data

Estimation of immune cell content in tumour tissue using single-cell RNA-seq data

Mathematical approaches can be used to assess immune cell composition from the tumour's bulk expression data. Here the authors optimise the CYBERSORT-based deconvolution algorithm by including cell type-specific reference gene expression profiles generated from tumour-derived single-cell RNA se...

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Bibliographic Details
Main Authors: Max Schelker, Sonia Feau, Jinyan Du, Nav Ranu, Edda Klipp, Gavin MacBeath, Birgit Schoeberl, Andreas Raue
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02289-3

Internet

https://doi.org/10.1038/s41467-017-02289-3

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