Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: pathophysiology of biliary lipid secretion1

Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: pathophysiology of biliary lipid secretion1

The inbred C57L strain but not the AKR strain of mice carry Lith genes that determine cholesterol gallstone susceptibility. When C57L mice are fed a lithogenic diet containing 15% fat, 1% cholesterol, and 0.5% cholic acid, gallbladder bile displays rapid cholesterol supersaturation, mucin gel accumu...

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Bibliographic Details
Main Authors: David Q-H. Wang, Frank Lammert, Beverly Paigen, Martin C. Carey
Format: Article
Language:English
Published: Elsevier 1999-11-01
Series:Journal of Lipid Research
Subjects:
gallstones
enterohepatic circulation
genetics
phase diagrams
pool size
bile salt species
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520324305

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http://www.sciencedirect.com/science/article/pii/S0022227520324305

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