Complement C3 overexpression activates JAK2/STAT3 pathway and correlates with gastric cancer progression

Complement C3 overexpression activates JAK2/STAT3 pathway and correlates with gastric cancer progression

Abstract Background Localized C3 deposition is a well-known factor of inflammation. However, its role in oncoprogression of gastric cancer (GC) remains obscured. This study aims to explore the prognostic value of C3 deposition and to elucidate the mechanism of C3-related oncoprogression for GC. Meth...

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Bibliographic Details
Main Authors: Kaitao Yuan, Jinning Ye, Zhenguo Liu, Yufeng Ren, Weiling He, Jianbo Xu, Yulong He, Yujie Yuan
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Complement
Gastric cancer
Immune signature
Tumor stage
STAT3
Prognosis prediction
Online Access:https://doi.org/10.1186/s13046-019-1514-3

Internet

https://doi.org/10.1186/s13046-019-1514-3

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