Effects of low-dose rate γ-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse heart.

Effects of low-dose rate γ-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse heart.

PURPOSE:Space travel is associated with an exposure to low-dose rate ionizing radiation and the microgravity environment, both of which may lead to impairments in cardiac function. We used a mouse model to determine short- and long-term cardiac effects to simulated microgravity (hindlimb unloading;...

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Bibliographic Details
Main Authors: John W Seawright, Yusra Samman, Vijayalakshmi Sridharan, Xiao Wen Mao, Maohua Cao, Preeti Singh, Stepan Melnyk, Igor Koturbash, Gregory A Nelson, Martin Hauer-Jensen, Marjan Boerma
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5498037?pdf=render

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http://europepmc.org/articles/PMC5498037?pdf=render

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