Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying an A79V mutation in PSEN1

Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying an A79V mutation in PSEN1

Skin fibroblasts were obtained from a 48-year-old presymptomatic woman carrying a A79V mutation in the presenilin 1 gene (PSEN1), causing Alzheimer's disease (AD). Induced pluripotent stem cell (iPSCs) were derived via transfection with episomal vectors carrying hOCT4, hSOX2, hKLF2, hL-MYC, hLI...

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Bibliographic Details
Main Authors: Tong Li, Carlota Pires, Troels T. Nielsen, Gunhild Waldemar, Lena E. Hjermind, Jørgen E. Nielsen, Andras Dinnyes, Poul Hyttel, Kristine K. Freude
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S187350611600012X

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http://www.sciencedirect.com/science/article/pii/S187350611600012X

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