The crosstalk between HIFs and mitochondrial dysfunctions in cancer development

Abstract Mitochondria are essential cellular organelles that are involved in regulating cellular energy, metabolism, survival, and proliferation. To some extent, cancer is a genetic and metabolic disease that is closely associated with mitochondrial dysfunction. Hypoxia-inducible factors (HIFs), whi...

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Bibliographic Details
Main Authors: Xingting Bao, Jinhua Zhang, Guomin Huang, Junfang Yan, Caipeng Xu, Zhihui Dou, Chao Sun, Hong Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03505-1