Blocking IL-10 signaling with soluble IL-10 receptor restores in vitro specific lymphoproliferative response in dogs with leishmaniasis caused by Leishmania infantum.

Blocking IL-10 signaling with soluble IL-10 receptor restores in vitro specific lymphoproliferative response in dogs with leishmaniasis caused by Leishmania infantum.

rIL-10 plays a major role in restricting exaggerated inflammatory and immune responses, thus preventing tissue damage. However, the restriction of inflammatory and immune responses by IL-10 can also favor the development and/or persistence of chronic infections or neoplasms. Dogs that succumb to can...

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Bibliographic Details
Main Authors: Catiule de Oliveira Santos, Sidnei Ferro Costa, Fabiana Santana Souza, Jessica Mariane Ferreira Mendes, Cristiane Garboggini Melo de Pinheiro, Diogo Rodrigo de Magalhães Moreira, Luciano Kalabric Silva, Valeria Marçal Felix de Lima, Geraldo Gileno de Sá Oliveira
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0239171

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https://doi.org/10.1371/journal.pone.0239171

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