Poly‐aneuploid cancer cells promote evolvability, generating lethal cancer

Abstract Cancer cells utilize the forces of natural selection to evolve evolvability allowing a constant supply of heritable variation that permits a cancer species to evolutionary track changing hazards and opportunities. Over time, the dynamic tumor ecosystem is exposed to extreme, catastrophic ch...

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Bibliographic Details
Main Authors: Kenneth J. Pienta, Emma U. Hammarlund, Robert Axelrod, Joel S. Brown, Sarah R. Amend
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:Evolutionary Applications
Subjects:
Online Access:https://doi.org/10.1111/eva.12929