Poly‐aneuploid cancer cells promote evolvability, generating lethal cancer
Abstract Cancer cells utilize the forces of natural selection to evolve evolvability allowing a constant supply of heritable variation that permits a cancer species to evolutionary track changing hazards and opportunities. Over time, the dynamic tumor ecosystem is exposed to extreme, catastrophic ch...
Main Authors: | Kenneth J. Pienta, Emma U. Hammarlund, Robert Axelrod, Joel S. Brown, Sarah R. Amend |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2020-08-01
|
Series: | Evolutionary Applications |
Subjects: | |
Online Access: | https://doi.org/10.1111/eva.12929 |
Similar Items
-
Tamoxifen is a candidate first‐in‐class inhibitor of acid ceramidase that reduces amitotic division in polyploid giant cancer cells—Unrecognized players in tumorigenesis
by: Shai White‐Gilbertson, et al.
Published: (2020-05-01) -
Synthetic Lethality in Lung Cancer—From the Perspective of Cancer Genomics
by: Iwao Shimomura, et al.
Published: (2019-03-01) -
Outcomes of resection for colorectal cancer hepatic metastases stratified by evolving eras of treatment
by: Chan Kun-Ming, et al.
Published: (2011-12-01) -
Inherited DNA Repair Gene Mutations in Men with Lethal Prostate Cancer
by: Tommi Rantapero, et al.
Published: (2020-03-01) -
Transposable elements in cancer as a by-product of stress-induced evolvability
by: Tobias eMourier, et al.
Published: (2014-05-01)