Proteomic Analysis of Urinary Extracellular Vesicles Reveals a Role for the Complement System in Medullary Sponge Kidney Disease

Medullary sponge kidney (MSK) disease is a rare and neglected kidney condition often associated with nephrocalcinosis/nephrolithiasis and cystic anomalies in the precalyceal ducts. Little is known about the pathogenesis of this disease, so we addressed the knowledge gap using a proteomics approach....

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Bibliographic Details
Main Authors: Maurizio Bruschi, Simona Granata, Giovanni Candiano, Antonia Fabris, Andrea Petretto, Gian Marco Ghiggeri, Giovanni Gambaro, Gianluigi Zaza
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:International Journal of Molecular Sciences
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Online Access:https://www.mdpi.com/1422-0067/20/21/5517