Homology-Directed Recombination for Enhanced Engineering of Chimeric Antigen Receptor T Cells

Homology-Directed Recombination for Enhanced Engineering of Chimeric Antigen Receptor T Cells

Gene editing by homology-directed recombination (HDR) can be used to couple delivery of a therapeutic gene cassette with targeted genomic modifications to generate engineered human T cells with clinically useful profiles. Here, we explore the functionality of therapeutic cassettes delivered by these...

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Bibliographic Details
Main Authors: Malika Hale, Baeckseung Lee, Yuchi Honaker, Wai-Hang Leung, Alexandra E. Grier, Holly M. Jacobs, Karen Sommer, Jaya Sahni, Shaun W. Jackson, Andrew M. Scharenberg, Alexander Astrakhan, David J. Rawlings
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
chimeric antigen receptor
gene editing
T cell
TCR
CCR5
CD19
BCMA
cell therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050117300025

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http://www.sciencedirect.com/science/article/pii/S2329050117300025

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