MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades

MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades

RNA virus infections are detected by the RIG-I family of receptors, which induce type-I interferons through the mitochondrial protein MAVS. MAVS forms large prion-like polymers that activate the cytosolic kinases IKK and TBK1, which in turn activate NF-κB and IRF3, respectively, to induce interferon...

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Bibliographic Details
Main Authors: Siqi Liu, Jueqi Chen, Xin Cai, Jiaxi Wu, Xiang Chen, You-Tong Wu, Lijun Sun, Zhijian J Chen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-08-01
Series:eLife
Subjects:
MAVS
innate immunity
virus
ubiquitin
signaling
mitochondria
Online Access:https://elifesciences.org/articles/00785

Internet

https://elifesciences.org/articles/00785

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