From understanding cellular function to novel drug discovery: the role of planar patch-clamp array chip technology

From understanding cellular function to novel drug discovery: the role of planar patch-clamp array chip technology

All excitable cell functions rely upon ion channels that are embedded in their plasma membrane. Perturbations of ion channel structure or function result in pathologies ranging from cardiac dysfunction to neurodegenerative disorders. Consequently, to understand the functions of excitable cells and t...

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Bibliographic Details
Main Authors: Christophe ePy, Marzia eMartina, Gerardo A Diaz-Quijada, Collin C Luk, Dolores eMartinez, Mike W Denhoff, Anne eCharrier, Tanya eComas, Robert eMonette, Anthony eKrantis, Naweed I Syed, Geoffrey A.R. Mealing
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-10-01
Series:Frontiers in Pharmacology
Subjects:
Synaptic Transmission
cell placement
chemical patterning
cultured neuron
giga-seal
patch-clamp whole-cell recordings
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00051/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00051/full

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