ApoE4 attenuates cortical neuronal activity in young behaving apoE4 rats
The E4 allele of apolipoprotein E (apoE4) is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). However, apoE4 may cause innate brain abnormalities before the appearance of AD-related neuropathology. Understanding these primary dysfunctions is vital for the early detecti...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2021-07-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996121001224 |