No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice

No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice

Abstract Base excision repair (BER) is a major pathway for removal of DNA base lesions and maintenance of genomic stability, which is essential in cancer prevention. DNA glycosylases recognize and remove specific lesions in the first step of BER. The existence of a number of these enzymes with overl...

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Bibliographic Details
Main Authors: Veslemøy Rolseth, Luisa Luna, Ann Karin Olsen, Rajikala Suganthan, Katja Scheffler, Christine G. Neurauter, Ying Esbensen, Anna Kuśnierczyk, Gunn A. Hildrestrand, Anne Graupner, Jill M. Andersen, Geir Slupphaug, Arne Klungland, Hilde Nilsen, Magnar Bjørås
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-04472-4

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https://doi.org/10.1038/s41598-017-04472-4

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