Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents

Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents

(Hetero)aryl substituted saturated cyclic amines are ubiquitous scaffolds in biologically active molecules. Metal-catalyzed cross-couplings between halogeno N-heterocycles and organometallic species are efficient and modular reactions to access these attractive scaffolds. An overview of our work con...

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Bibliographic Details
Main Authors: Baptiste Barré, Laurine Gonnard, Amandine Guérinot, Janine Cossy
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Molecules
Subjects:
N-heterocycle
piperidine
pyrrolidine
azetidine
cross-coupling
cobalt
Grignard reagent
Online Access:http://www.mdpi.com/1420-3049/23/6/1449

Internet

http://www.mdpi.com/1420-3049/23/6/1449

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