Enhancing PLP-Binding Capacity of Class-III ω-Transaminase by Single Residue Substitution

Enhancing PLP-Binding Capacity of Class-III ω-Transaminase by Single Residue Substitution

Transaminases are pyridoxal-5′-phosphate (PLP) binding enzymes, broadly studied for their potential industrial application. Their affinity for PLP has been related to their performance and operational stability and while significant differences in PLP requirements have been reported, the environment...

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Bibliographic Details
Main Authors: David Roura Padrosa, Raphael Alaux, Phillip Smith, Ingrid Dreveny, Fernando López-Gallego, Francesca Paradisi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
pyridoxal phosphate
protein stability
protein engineering
biocatalysis
transaminase
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2019.00282/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2019.00282/full

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