Bellidifolin Ameliorates Isoprenaline-Induced Myocardial Fibrosis by Regulating TGF-β1/Smads and p38 Signaling and Preventing NR4A1 Cytoplasmic Localization

Bellidifolin Ameliorates Isoprenaline-Induced Myocardial Fibrosis by Regulating TGF-β1/Smads and p38 Signaling and Preventing NR4A1 Cytoplasmic Localization

Myocardial fibrosis is closely related to high morbidity and mortality. In Inner Mongolia, Gentianella amarella subsp. acuta (Michx.) J.M.Gillett (G. acuta) is a kind of tea used to prevent cardiovascular diseases. Bellidifolin (BEL) is an active xanthone molecule from G. acuta that protects against...

Full description

Bibliographic Details
Main Authors: Hong-Xia Yang, Jia-Huan Sun, Ting-Ting Yao, Yuan Li, Geng-Rui Xu, Chuang Zhang, Xing-Chao Liu, Wei-Wei Zhou, Qiu-Hang Song, Yue Zhang, Ai-Ying Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
bellidifolin
Gentianella acuta
myocardial fibrosis
TGF-β1/smads pathway
p38
orphan nuclear receptor NR4A1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.644886/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.644886/full

Similar Items