A Cell‐free DNA Barcode‐Enabled Single‐Molecule Test for Noninvasive Prenatal Diagnosis of Monogenic Disorders: Application to β‐Thalassemia

A Cell‐free DNA Barcode‐Enabled Single‐Molecule Test for Noninvasive Prenatal Diagnosis of Monogenic Disorders: Application to β‐Thalassemia

Abstract Noninvasive prenatal testing of common aneuploidies has become routine over the past decade, but testing of monogenic disorders remains a challenge in clinical implementation. Most recent studies have inherent limitations, such as complicated procedures, a lack of versatility, and the need...

Full description

Bibliographic Details
Main Authors: Xingkun Yang, Qinghua Zhou, Wanjun Zhou, Mei Zhong, Xiaoling Guo, Xiaofeng Wang, Xin Fan, Shanhuo Yan, Liyan Li, Yunli Lai, Yongli Wang, Jin Huang, Yuhua Ye, Huaping Zeng, Jun Chuan, Yuanping Du, Chouxian Ma, Peining Li, Zhuo Song, Xiangmin Xu
Format: Article
Language:English
Published: Wiley 2019-06-01
Series:Advanced Science
Subjects:
β‐thalassemia
cell‐free DNA barcode‐enabled single‐molecule test (cfBEST)
molecule counting system
monogenic disorders
noninvasive prenatal diagnosis (NIPD)
Online Access:https://doi.org/10.1002/advs.201802332

Internet

https://doi.org/10.1002/advs.201802332

Similar Items