Inhibition of mitochondrial carrier homolog 2 (MTCH2) suppresses tumor invasion and enhances sensitivity to temozolomide in malignant glioma

Inhibition of mitochondrial carrier homolog 2 (MTCH2) suppresses tumor invasion and enhances sensitivity to temozolomide in malignant glioma

Abstract Background Malignant glioma exerts a metabolic shift from oxidative phosphorylation (OXPHOs) to aerobic glycolysis, with suppressed mitochondrial functions. This phenomenon offers a proliferation advantage to tumor cells and decrease mitochondria-dependent cell death. However, the underlyin...

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Bibliographic Details
Main Authors: Qiuyun Yuan, Wanchun Yang, Shuxin Zhang, Tengfei Li, Mingrong Zuo, Xingwang Zhou, Junhong Li, Mao Li, Xiaoqiang Xia, Mina Chen, Yanhui Liu
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Molecular Medicine
Subjects:
MTCH2
Glioma
Temozolomide
Mitochondria
Cell migration/invasion
Cell death
Online Access:https://doi.org/10.1186/s10020-020-00261-4

Internet

https://doi.org/10.1186/s10020-020-00261-4

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