Suppression of Human Platelet Activation via Integrin α<sub>IIb</sub>β<sub>3</sub> Outside-In Independent Signal and Reduction of the Mortality in Pulmonary Thrombosis by Auraptene

Suppression of Human Platelet Activation via Integrin α<sub>IIb</sub>β<sub>3</sub> Outside-In Independent Signal and Reduction of the Mortality in Pulmonary Thrombosis by Auraptene

Auraptene is the most abundant coumarin derivative from plants. The pharmacological value of this compound has been well demonstrated, especially in the prevention of cancer and neurodegenerative diseases. Platelet activation is a major factor contributing to arterial thrombosis. Thus, this study ev...

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Bibliographic Details
Main Authors: Chih-Wei Hsia, Cheng-Lin Tsai, Joen-Rong Sheu, Wan-Jung Lu, Chih-Hsuan Hsia, Marappan Velusamy, Thanasekaran Jayakumar, Jiun-Yi Li
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:International Journal of Molecular Sciences
Subjects:
auraptene
human platelet
arterial thrombosis
erk1/2/jnk1/2
experimental mice
Online Access:https://www.mdpi.com/1422-0067/20/22/5585

Internet

https://www.mdpi.com/1422-0067/20/22/5585

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