Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid

Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid

Abstract Background Microglia are multifunctional cells that are primarily neuroprotective and a deficit in their functional integrity is likely to be a contributory factor in the deteriorating neuronal function that occurs with age and neurodegeneration. One aspect of microglial dysfunction is redu...

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Bibliographic Details
Main Authors: Ana Rubio-Araiz, Orla M. Finucane, Samuel Keogh, Marina A. Lynch
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Journal of Neuroinflammation
Subjects:
Toll-like receptor 2 (TLR2)
Amyloid-β (Aβ)
Microglia
Neuroinflammation
Glycolysis
Oxidative metabolism
Online Access:http://link.springer.com/article/10.1186/s12974-018-1281-7

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http://link.springer.com/article/10.1186/s12974-018-1281-7

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