Symptom heterogeneity in Huntington's disease correlates with neuronal degeneration in the cerebral cortex

Symptom heterogeneity in Huntington's disease correlates with neuronal degeneration in the cerebral cortex

Background: Huntington's disease (HD) is characterised by variable symptoms and neuropathology of the basal ganglia and cortex. Previously, we have shown that the pattern of pyramidal cell loss in 8 different cortical regions correlates with the phenotypic variability in HD. In the primary moto...

Full description

Bibliographic Details
Main Authors: Nasim F. Mehrabi, PhD, Henry J. Waldvogel, PhD, Lynette J. Tippett, PhD, Virginia M. Hogg, MD, Beth J. Synek, MD, Richard L.M. Faull, MBChB, PhD, DSc
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Neurobiology of Disease
Subjects:
Huntington's disease
Cerebral cortex
Interneurons
Pyramidal cells
Pathology
Variable symptoms
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116302169

Internet

http://www.sciencedirect.com/science/article/pii/S0969996116302169

Similar Items