Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis

Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis

The LXR-SREBP1c pathway promotes hepatic lipogenesis that is deregualted in fatty liver disease. Here the authors show that the long noncoding RNA Blnc1 contributes to the development of obesity-driven steatosis by enabling SREBP1c trascriptional activity in response to LXR activation.

Bibliographic Details
Main Authors: Xu-Yun Zhao, Xuelian Xiong, Tongyu Liu, Lin Mi, Xiaoling Peng, Crystal Rui, Liang Guo, Siming Li, Xiaoying Li, Jiandie D. Lin
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05383-2

Internet

https://doi.org/10.1038/s41467-018-05383-2

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