Nuclear deformation mediates liver cell mechanosensing in cirrhosis

Nuclear deformation mediates liver cell mechanosensing in cirrhosis

Background & Aims: Liver stiffness is increased in advanced chronic liver disease (ACLD) and accurately predicts prognosis in this population. Recent data suggest that extracellular matrix stiffness per se may modulate the phenotype of liver cells. We aimed at investigating the effect of mat...

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Bibliographic Details
Main Authors: Sergi Guixé-Muntet, Martí Ortega-Ribera, Cong Wang, Sonia Selicean, Ion Andreu, Jenny Z. Kechagia, Constantino Fondevila, Pere Roca-Cusachs, Jean-François Dufour, Jaime Bosch, Annalisa Berzigotti, Jordi Gracia-Sancho
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:JHEP Reports
Subjects:
Chronic liver disease
Hepatocyte
HSC
LSEC
Stiffness
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555920300793

Internet

http://www.sciencedirect.com/science/article/pii/S2589555920300793

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