Aggregated and Hyperstable Damage-Associated Molecular Patterns Are Released During ER Stress to Modulate Immune Function

Aggregated and Hyperstable Damage-Associated Molecular Patterns Are Released During ER Stress to Modulate Immune Function

Chronic ER stress occurs when protein misfolding in the Endoplasmic reticulum (ER) lumen remains unresolved despite activation of the unfolded protein response. We have shown that traumatic injury such as a severe burn leads to chronic ER stress in vivo leading to systemic inflammation which can las...

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Bibliographic Details
Main Authors: Alexander Andersohn, M. Iveth Garcia, Ying Fan, Max C. Thompson, Askar M. Akimzhanov, Abdikarim Abdullahi, Marc G. Jeschke, Darren Boehning
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ER stress
damage-associated molecular pattern
DAMP
cytokine
dendritic cell
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00198/full

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https://www.frontiersin.org/article/10.3389/fcell.2019.00198/full

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