Granulocyte colony-stimulating factor activating HIF-1alpha acts synergistically with erythropoietin to promote tissue plasticity.

Stroke and peripheral limb ischemia are serious clinical problems with poor prognosis and limited treatment. The cytokines erythropoietin (EPO) and granulocyte-colony stimulating factor (G-CSF) have been used to induce endogenous cell repair and angiogenesis. Here, we demonstrated that the combinati...

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Main Authors: Shih-Ping Liu, Shin-Da Lee, Hsu-Tung Lee, Demeral David Liu, Hsiao-Jung Wang, Ren-Shyan Liu, Shinn-Zong Lin, Ching-Yuan Su, Hung Li, Woei-Cherng Shyu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2852409?pdf=render