The methyl donor S-adenosylmethionine prevents liver hypoxia and dysregulation of mitochondrial bioenergetic function in a rat model of alcohol-induced fatty liver disease

The methyl donor S-adenosylmethionine prevents liver hypoxia and dysregulation of mitochondrial bioenergetic function in a rat model of alcohol-induced fatty liver disease

Background: Mitochondrial dysfunction and bioenergetic stress play an important role in the etiology of alcoholic liver disease. Previous studies from our laboratory show that the primary methyl donor S-Adenosylmethionine (SAM) minimizes alcohol-induced disruptions in several mitochondrial functions...

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Bibliographic Details
Main Authors: Adrienne L. King, Sudheer K. Mantena, Kelly K. Andringa, Telisha Millender-Swain, Kimberly J. Dunham-Snary, Claudia R. Oliva, Corinne E. Griguer, Shannon M. Bailey
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Redox Biology
Subjects:
Liver
Alcohol
S-Adenosylmethionine
Mitochondria
Hypoxia
Nitric oxide
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231716300829

Internet

http://www.sciencedirect.com/science/article/pii/S2213231716300829

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