Presence of diabetes autoantigens in extracellular vesicles derived from human islets

Abstract Beta-cell (β-cell) injury is the hallmark of autoimmune diabetes. However, the mechanisms by which autoreactive responses are generated in susceptible individuals are not well understood. Extracellular vesicles (EV) are produced by mammalian cells under normal and stressed physiological sta...

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Bibliographic Details
Main Authors: Craig P. Hasilo, Sarita Negi, Isabelle Allaeys, Nathalie Cloutier, Alissa K. Rutman, Marco Gasparrini, Éric Bonneil, Pierre Thibault, Éric Boilard, Steven Paraskevas
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-04977-y