LDL receptor blockade reduces mortality in a mouse model of ischaemic stroke without improving tissue-type plasminogen activator-induced brain haemorrhage: towards pre-clinical simulation of symptomatic ICH

LDL receptor blockade reduces mortality in a mouse model of ischaemic stroke without improving tissue-type plasminogen activator-induced brain haemorrhage: towards pre-clinical simulation of symptomatic ICH

Abstract Background Symptomatic intracerebral haemorrhage (sICH) following tissue-type plasminogen activator (rt-PA) administration is the most feared and lethal complication of thrombolytic therapy for ischaemic stroke, creating a significant obstacle for a broader uptake of this beneficial treatme...

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Bibliographic Details
Main Authors: Be’eri Niego, Brad R. S. Broughton, Heidi Ho, Christopher G. Sobey, Robert L. Medcalf
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Fluids and Barriers of the CNS
Subjects:
Stroke
Tissue-type plasminogen activator
Symptomatic intracerebral haemorrhage
Blood–brain barrier
Receptor-associated protein
MCAo
Online Access:http://link.springer.com/article/10.1186/s12987-017-0081-2

Internet

http://link.springer.com/article/10.1186/s12987-017-0081-2

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