Human monocyte-to-macrophage differentiation involves highly localized gain and loss of DNA methylation at transcription factor binding sites

Human monocyte-to-macrophage differentiation involves highly localized gain and loss of DNA methylation at transcription factor binding sites

Abstract Background Macrophages and their precursors monocytes play a key role in inflammation and chronic inflammatory disorders. Monocyte-to-macrophage differentiation and activation programs are accompanied by significant epigenetic remodeling where DNA methylation associates with cell identity....

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Bibliographic Details
Main Authors: Koen F. Dekkers, Annette E. Neele, J. Wouter Jukema, Bastiaan T. Heijmans, Menno P. J. de Winther
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Epigenetics & Chromatin
Subjects:
DNA methylation
Differentiation
Epigenomics
Macrophage
Monocyte
Transcription factor
Online Access:http://link.springer.com/article/10.1186/s13072-019-0279-4

Internet

http://link.springer.com/article/10.1186/s13072-019-0279-4

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