Hard wiring of normal tissue-specific chromosome-wide gene expression levels is an additional factor driving cancer type-specific aneuploidies

Hard wiring of normal tissue-specific chromosome-wide gene expression levels is an additional factor driving cancer type-specific aneuploidies

Abstract Background Many carcinomas have recurrent chromosomal aneuploidies specific to the tissue of tumor origin. The reason for this specificity is not completely understood. Methods In this study, we looked at the frequency of chromosomal arm gains and losses in different cancer types from the T...

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Main Authors: Sushant Patkar, Kerstin Heselmeyer-Haddad, Noam Auslander, Daniela Hirsch, Jordi Camps, Daniel Bronder, Markus Brown, Wei-Dong Chen, Rachel Lokanga, Darawalee Wangsa, Danny Wangsa, Yue Hu, Annette Lischka, Rüdiger Braun, Georg Emons, B. Michael Ghadimi, Jochen Gaedcke, Marian Grade, Cristina Montagna, Yuri Lazebnik, Michael J. Difilippantonio, Jens K. Habermann, Gert Auer, Eytan Ruppin, Thomas Ried
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Genome Medicine
Online Access:https://doi.org/10.1186/s13073-021-00905-y

Internet

https://doi.org/10.1186/s13073-021-00905-y

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