The Human ABCG1 Transporter Mobilizes Plasma Membrane and Late Endosomal Non-Sphingomyelin-Associated-Cholesterol for Efflux and Esterification

The Human ABCG1 Transporter Mobilizes Plasma Membrane and Late Endosomal Non-Sphingomyelin-Associated-Cholesterol for Efflux and Esterification

We have previously shown that GFP-tagged human ABCG1 on the plasma membrane (PM) and in late endosomes (LE) mobilizes sterol on both sides of the membrane lipid bilayer, thereby increasing cellular cholesterol efflux to lipid surfaces. In the present study, we examined ABCG1-induced changes in membr...

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Bibliographic Details
Main Authors: Edward B. Neufeld, Katherine O'Brien, Avram D. Walts, John A. Stonik, Daniela Malide, Christian A. Combs, Alan T. Remaley
Format: Article
Language:English
Published: MDPI AG 2014-12-01
Series:Biology
Subjects:
ABCG1
cholesterol
cholesterol efflux
vesicular trafficking
HDL
rescretion
Online Access:http://www.mdpi.com/2079-7737/3/4/866

Internet

http://www.mdpi.com/2079-7737/3/4/866

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