CTLA4 has a profound impact on the landscape of tumor-infiltrating lymphocytes with a high prognosis value in clear cell renal cell carcinoma (ccRCC)

CTLA4 has a profound impact on the landscape of tumor-infiltrating lymphocytes with a high prognosis value in clear cell renal cell carcinoma (ccRCC)

Abstract Background Cytotoxic T-lymphocyte associated protein 4 (CTLA4) inhibitors have been shown to significantly prolong the overall survival (OS) in a wide range of cancers. However, its application in clear cell renal cell carcinoma (ccRCC) is limited due to the therapy response, and the progno...

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Bibliographic Details
Main Authors: Shiyi Liu, Feiyan Wang, Wei Tan, Li Zhang, Fangfang Dai, Yanqing Wang, Yaqi Fan, Mengqin Yuan, Dongyong Yang, Yajing Zheng, Zhimin Deng, Yeqiang Liu, Yanxiang Cheng
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Cancer Cell International
Subjects:
CTLA4
Clear cell renal cell carcinoma
Tumor microenvironment
Tumor-infiltrating lymphocytes
Prognosis
CD8+ T cells
Online Access:http://link.springer.com/article/10.1186/s12935-020-01603-2

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http://link.springer.com/article/10.1186/s12935-020-01603-2

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